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ORIGINAL ARTICLE
Year : 2021  |  Volume : 11  |  Issue : 5  |  Page : 582-587

Possible role of Porphyromonas gingivalis in the regulation of E2F1, CDK11, and iNOS gene expression in neuronal cell cycle: A preliminary study


Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Correspondence Address:
Prof. Endang W Bachtiar
Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Salemba Raya, No. 4, Jakarta Pusat.
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jispcd.JISPCD_108_21

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Objective: This study aimed at evaluating the in vitro effect of Porphyromonas gingivalis exposure in gene expression of E2F1 (family of transcription factors), cyclin-dependent kinase-1 (CDK11), and inducible nitric oxide synthase (iNOS) of the neuronal cell cycle. Materials and Methods: The culture of neuronal cell line SH-SY5Y was exposed to P. gingivalis ATCC 33277, and the gene expression of E2F1, CDK11, and iNOS was analyzed by using a real-time polymerase chain reaction. Results: It was shown that E2F1, a G1 phase biomarker and transcription factor, was upregulated in neuronal cells exposed to P. gingivalis compared with that in control cells. However, CDK11, a biomarker of G2/M checkpoint and iNOS, was downregulated in neuronal cells exposed to P. gingivalis compared with that in control cells. Conclusions: P. gingivalis can regulate the neuronal cell cycle, as indicated in the E2F1, CDK11, and iNOS gene expression.


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