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   2016| December  | Volume 6 | Issue 9  
    Online since December 30, 2016

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Role of odanacatib in reducing bone loss due to endodontic disease: An overview
Rachana Bahuguna, Atul Jain, Suleman Abbas Khan, MS Arvind
December 2016, 6(9):175-181
DOI:10.4103/2231-0762.197183  PMID:28217533
Aims and Objectives: Through a comprehensive literature review, this article provides an overview of the potential role of odanacatib (ODN) in reducing bone loss due to endodontic disease. Materials and Methods: A literature review was performed in PubMed Central, MEDLINE, Cochrane Library, and EBSCO databases. The articles identified included those published between 2002 and 2016. Based on the predetermined inclusion and exclusion criteria, out of 237 articles found, 50 were selected for this review. Results: Cathepsin K (CstK), which is indispensible to the immune system, also plays an important role in osteoclastic bone resorption. ODN, which is an orally active, selective, and effective inhibitor of CstK, decreases bone resorption by selectively inhibiting proteolysis of matrix proteins by CstK, without affecting other osteoclastic activity or osteoblast viability. Conclusion: The goal of endodontic treatment is to achieve a clinically asymptomatic state along with formation of reparative bone. This process could take 6 months or longer, hence, an earlier reversal of the resorption process could lead to faster healing and resolution of the periapical lesion. Use of ODN can be of help in achieving this goal.
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Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars
Tejpal Singh, Vinayak More, Umayra Fatima, Tanveer Karpe, Mohammed A Aleem, J Prameela
December 2016, 6(9):197-204
DOI:10.4103/2231-0762.197192  PMID:28217537
Aims and Objectives: To evaluate the effect of bromelain on pain and swelling after surgical removal of third molars. Materials and Methods: A prospective randomized clinical study was conducted among 40 patients requiring surgical removal of impacted mandibular third molars. All the impacted molars were surgically removed, and the patients were administered bromelain along with amoxicillin. Patients were recalled on day 1, day 3, and day 7 for postoperative pain assessment using visual analogue scale (VAS) and postoperative swelling assessment using facial reference points tragus and pogonion. VAS score was statistically analyzed using repeated analysis of variance with post-hoc Bonferroni test postoperatively on day 1, day 3, and day 7 using the Statistical Package for the Social Sciences software version 14. Results: Out of the total 40 patients, bromelain was effective in 28 (70%) patients. In these patients, there was reduction in swelling and pain after taking bromelain. Conclusion: Bromelain can be used as a successful oral enzyme therapy for oral surgery patients, especially after removal of impacted third molars.
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Effect of fluoridated water on intelligence in 10-12-year-old school children
A Aravind, RS Dhanya, Ajay Narayan, George Sam, VJ Adarsh, M Kiran
December 2016, 6(9):237-242
DOI:10.4103/2231-0762.197204  PMID:28217543
Aim: The aim of the present study was to evaluate the relationship of drinking water fluoride levels with children's intelligence quotient (IQ). Materials and Methods: Water was collected from initially identified endemic fluoride regions according to the geological research of Government of India. Fluoride concentration of the water was assessed by utilizing fluoride ion selective electrode, Orion 9609BN, and categorized on the basis of fluoride concentration into low, medium, and high-fluoride regions, i.e., Virajpet (low fluoride level < 1.2 ppm), Banavara (Medium fluoride level 1.2-2 ppm), and Mastihalli (High fluoride levels > 3 ppm). Government school from all three villages were selected randomly and IQ levels were assessed by using Raven's Standard Progressive Matrices. This test was conducted on each child in the study sample. Results: A significant inverse relationship was found between the fluoride concentration in drinking water and IQ (r value = −0.204; P < 0.000). It was observed that IQ level was negatively correlated with fluoride concentration in drinking water. Conclusion: It is concluded that IQ level was negatively correlated with fluoride level in drinking water. Factors that might affect children's IQ need to be considered, and it is necessary to devise solutions for preventing the harmful effects of excessive intake of fluoride ion to the body.
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Correlating the clinical assessment of impacted mandibular third molars with panoramic radiograph and intraoral periapical radiograph
P Vani Priya, Fazil A Nasyam, M Ramprasad, Narendra V Penumatsa, Syed Akifuddin, Sandeep
December 2016, 6(9):219-225
DOI:10.4103/2231-0762.197198  PMID:28217540
Aims And Objectives: This study was conducted to compare the clinical assessment of impacted third molars of mandible with panaromic radiograph (OPG) and intraoral periapical radiograph (IOPA) and to assess the efficacy of IOPA and. Moreover, we corroborated the OPG and IOPA findings of impacted mandiblar third molar root apex to inferior alveolar canal. Materials and Methods: A total of 200 patients with pericoronitis were examined who were indicated for surgical extraction, among which 50 patients were selected for the study. All the patients underwent a radiographic survey with a digital OPG and IOPA of impacted mandibular third molars, along with clinical survey for anatomic relationship, type of impaction, space available, position in relation to second molar, number of roots, root curvature, and proximity of nerve canal. The data was subjected to statistical analysis. The Statistical Package for Social Sciences version 4.0.1 software was used for analyzing the collected data. Results: The study revealed that IOPA was more accurate in determining a majority of the factors affecting the third molar surgery, including relationship of the external oblique ridge (IOPA vs OPG = 96%:90%), anteroposterior relation with ramus (IOPA vs OPG = 70%:66%), vertical depth of impaction (IOPA vs OPG = 72%:68%), number of roots (P = 0.013), morphology of roots (IOPA vs OPG = 96%:90%); however, OPG was found to be accurate in evaluating the type of impaction (IOPA vs OPG = 88%:94%), canal relation, along with root of impacted molar (IOPA vs OPG = 74%:86%). Conclusion: To conclude, although IOPA has a marginal angle over OPG in assessing various parameters, only the number of roots have a greater accuracy (P < 0.0013) in IOPA than with OPG. However, the OPG is the better choice to be considered when the patient is associated with trismus.
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Assessment of facial golden proportions among central Indian population
Rathore Saurabh, Bolya Piyush, Bhatt Sourabh, Ojha Preeti, Rutvik Trivedi, Pradeep Vishnoi
December 2016, 6(9):182-186
DOI:10.4103/2231-0762.197188  PMID:28217534
Aim: This study aimed to identify and establish the facial and smile proportions in young adults and to compare the results with ideal or divine proportions, compare the proportions of males and females included in our study population and compare them with those established for Caucasian and Japanese populations. Materials and Methods: Two hundred participants (164 females, 36 males) with Angle's class I malocclusion (M.O). and well-balanced faces were selected and photographed in the frontal repose position. Analysis was done in Adobe Photoshop software. Statistical analysis was done using the Statistical Package for the Social Sciences version 17.0. (IBM Corporation Armonk, New York, United States). Results: Results suggested that females are more near to ideal ratios and males are more deviated from the ideal ratios. The proportions of males and females were not considerably different from each other. In Indian population, upper 3 rd facial height (TR-LC) was increased and mid-face height (LC-LN) was decreased; in lower 3 rd of the face, LN-CH was slightly increased in comparison to CH-ME. In facial widths, outer canthal width (LC-LC) was greater in the Indian population and mouth width (CH-CH) was normal. When compared with Indian population, Japanese participants had wider noses, outer canthal distance, and bitemporal width. Conclusion: It was concluded that significant difference was found between the proportions of the Indian population and ideal ratio. When Indian population was compared with Japanese and Caucasian populations, some parameters of facial proportions showed significant difference, which leads to the need for establishing standardized norms for various facial proportions in Indian population.
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Prevalence and pattern of partial edentulism among dental patients attending College of Dentistry, Aljouf University, Saudi Arabia
Mostafa I Fayad, Mohamed N Baig, Abdulrazaq M Alrawaili
December 2016, 6(9):187-191
DOI:10.4103/2231-0762.197189  PMID:28217535
Objective: The current study aimed to determine the prevalence and pattern of partial edentulism among dental patients attending the College of Dentistry, Aljouf University, Saudi Arabia. Patients and Methods: A total of 142 patients were selected, and the prevalence of partial edentulism among the selected patient was recorded. Patients were grouped into three age groups; Group I: 21-30 years, Group II: 31-40 years, and Group III: 41-50 years. Kennedy's classification was used to determine the pattern of partially edentulous arches. Modification areas were not included in the assessment to avoid complexity. Data was analyzed using the Statistical Package for the Social Sciences version 20.0 for windows. Results: The results showed that the occurrence of Kennedy Class III partial edentulism was 67.2 % in the maxillary arch and 64.1% in the mandibular arch. Followed by Class II in both maxillary and mandibular arch with an average of 16.3 % in maxillary arch and14.8% in the mandibular arch. Based on these results, class III has the highest prevalence in group II (31- 40 years). Class I and class II have the highest incidence among group III Patients (41-50 years). Conclusions: Among selected patients, Class III dental arch was the most prevalent pattern in maxillary and mandibular arches. Class IV being the least dominant pattern between all classes. There are a rise in Kennedy Class I and Kennedy Class II pattern and a decline in Class III and Class IV with an increase in age.
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Dental caries prevalence among type II diabetic and nondiabetic adults attending a hospital
Ekta A Malvania, Sona A Sheth, Ashish S Sharma, Saloni Mansuri, Faizan Shaikh, Saloni Sahani
December 2016, 6(9):232-236
DOI:10.4103/2231-0762.197202  PMID:28217542
Objectives: Diabetes mellitus (DM) is a common chronic metabolic disorder which affects millions of people. At present, India has the highest incidence of diabetes worldwide. Several oral lesions and conditions are associated with diabetes. However, there is a lack of consensus among researchers regarding the relationship between DM and dental caries. Hence, the present study was carried out to assess the dental caries prevalence among type II diabetic and nondiabetic adults attending a hospital in Ahmedabad city. Materials and Methods: A hospital-based cross-sectional study was conducted. One hundred and twenty diabetics individuals attending the diabetic Outpatient Department (OPD) and age and sex-matched 120 nondiabetic individuals from general OPD were included in the study. The data were gathered through semi-close-ended questionnaire and clinical examination. Dental caries was assessed by using the World Health Organization's 2013 proforma. Data was analyzed by applying Student's independent t-test or one-way analysis of variance. Results: Dental caries prevalence among the diabetic group was 73.33% and 33.33% among the nondiabetic group. Dental caries prevalence and mean dental caries was significantly higher among uncontrolled diabetic individuals than that among controlled diabetic individuals. Duration of the disease and dental caries prevalence did not show any significant difference. Conclusion: Dental caries prevalence was significantly high among diabetic individuals compared with nondiabetic individuals. Close collaboration between the patients, healthcare units, and oral health professionals could be a way of improving diabetic patients' general and oral health.
  5,062 416 18
Analysis of sugars and pH in commercially available soft drinks in Saudi Arabia with a brief review on their dental implications
Ali Mohamed Idris, Nandimandalam Venkata Vani, Dhafi A Almutari, Mohammed A Jafar, Nezar Boreak
December 2016, 6(9):192-196
DOI:10.4103/2231-0762.197190  PMID:28217536
Objective: To determine the amount of sugar and pH in commercially available soft drinks in Jazan, Saudi Arabia. This was further compared with their labeled values in order to inform the regulations. The effects of these drinks on teeth is reviewed. Materials and Methods: Ten brands of popular soft drinks including 6 regular carbonated drinks and 4 energy drinks were obtained from the local markets. Their pH was determined using a pH meter. The amount of total sugar, glucose, fructose, and sucrose was estimated using high performance liquid chromatography (using Dionex ICS 5000 ion chromatography) at the Saudi Food and Drug Authority. Descriptive statistics was done to obtain the mean and standard deviation. Intergroup comparison was performed using independent t-test, and the labeled and estimated values within the group were compared with paired t-test. Results: The labeled and estimated sugar in energy drinks (14.3 ± 0.48 and 15.6 ± 2.3, respectively) were higher than the carbonated drinks (11.2 ± 0.46 and 12.8 ± 0.99), which was statistically significant. In addition, there was a significant difference in the concentration of glucose in energy drinks (5.7 ± 1.7) compared to carbonated drinks (4.1 ± 1.4). The pH of these drinks ranged from 2.4 to 3.2. The differences between the estimated and labeled sugar in carbonated drinks showed statistical significance. Mild variation was observed in total sugar, glucose, fructose, and sucrose levels among different bottles of the same brand of these drinks. Conclusion: The low pH and high sugar content in these drinks are detrimental to dental health. Comparison of the estimated sugar with their labeled values showed variation in most of the brands. Preventive strategies should be implemented to reduce the health risks posed by these soft drinks.
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Urban and rural disparity in tobacco use and knowledge about oral cancer among adolescents: An epidemiological survey on 12 and 15-year school going students
Rajesh Sabnis, Kamtaram Sahu, Deepak Thakur, Sanidhya Surana, Heena Mazhar, Soumy Pandey
December 2016, 6(9):226-231
DOI:10.4103/2231-0762.197200  PMID:28217541
Aims and Objectives: To assess and compare the tobacco use prevalence; to understand and compare attitudes and knowledge related to tobacco use and its health impact among urban and rural students; and to assess urban and rural disparity in the use of tobacco among 12 and 15-year-old adolescents in the urban and rural schools in Chhattisgarh, India. Materials and Methods: A cross-sectional study was conducted among 12 and 15-year-old and urban and rural school going children in Durg District. Scientifically, based on the data obtained from the pilot study, sample size was calculated. A total of 1000 children were selected to be a part of the study and were interviewed face-to-face using a detailed pretested, close-ended questionnaire. The Statistical Package for the Social Sciences version 16.0 (SPSS Pvt. Ltd, Chicago, IL, USA) was used for the statistical analyses. Results: Prevalence of tobacco consumption was 48.8%. Males were involved predominantly in consuming tobacco. The knowledge and attitude was better in the school children of urban areas than the school children of rural areas; more of the urban school children were involved in smoking cigarette. Rural children outnumbered urban children in the smokeless tobacco consumption. Conclusion: Prevalence of tobacco consumption among school children remains high with a wide disparity among urban and rural children. There is an urgent need to have a rural orientation in the National Tobacco Control Program that is currently being developed by the Government of India and giving relevance to the youth.
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Prevalence of facial asymmetry in Tirupati population: A posteroanterior cephalometric and photographic study
M Radhika Reddy, Srinivasa R Bogavilli, V Raghavendra, Venkata S Polina, Shaik Z Basha, R Preetham
December 2016, 6(9):205-212
DOI:10.4103/2231-0762.197194  PMID:28217538
Aims and Objective: The human face is the most prominent aspect in human social interactions, and therefore, it seems reasonable opting for orthodontic treatment is to overcome psychosocial difficulties relating to facial and dental appearance and enhance the quality of life in doing so. Materials and Methods: Posteroanterior cephalograms and frontal photographs of 100 participants (50 males and 50 females) were analyzed to evaluate skeletal asymmetry by the analysis suggested by Grummons. Soft tissue facial asymmetry was analyzed by composite photographic analysis. The data were statistically analyzed using the Statistical Package for the Social Sciences version 16.0 software. Independent t-test was used to find the differences between different measurements. Results: All participants showed mild asymmetry and right-sided laterality. The difference between the right and left sides were statistically insignificant (P > 0.01). The test revealed that only Co distance was statistically significant (P < 0.01), and all the other values are not statistically significant. Conclusion: Composite photographs of hundred participants revealed that facedness is towards the right, however, this laterality was not statistically significant. Both posteroanterior cephalograms and composite photographs showed right-sided laterality. Gender difference in both skeletal and soft tissue asymmetry is not statistically significant.
  3,718 281 1
Comparative clinical and radiographic evaluation of mineralized cancellous bone allograft (puros ® ) and autogenous bone in the treatment of human periodontal intraosseous defects: 6-months follow-up study
B Ravinder Reddy, J Sudhakar, Nichenametla Rajesh, V Sandeep, Y Muralidhar Reddy, WR Gnana Sagar
December 2016, 6(9):248-253
DOI:10.4103/2231-0762.197207  PMID:28217545
Aims: Several materials have been introduced as bone grafts, i.e., autografts, allograft, xenografts, and alloplastic grafts, and studies have shown them to produce greater clinical bone defect fill than open flap debridement alone. The aim of this clinical and radiological 6-month study was to compare and evaluate the clinical outcome of deep intraosseous defects following reconstructive surgery with the use of mineralized cancellous bone allograft (Puros ® ) or autogenous bone. Materials and Methods: Ten patients with 12 sites exhibiting signs of moderate generalized chronic periodontitis were enrolled in the study. The investigations were confined to two and three-walled intra bony defects with a preoperative probing depth of ≥5 mm. Six of these defects were treated with Puros ® (group A) the remaining six were treated with autogenous bone graft (group B). Allocation to the two groups was randomized. The clinical parameters, plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and bone fill, were recorded at different time intervals at the baseline, 1 month, 3 months, and 6 months. Intraoral radiographs were taken using standardized paralleling cone technique at baseline, 1, 3, and 6 months. Statistical analysis was done by using the one-way analysis of variance (ANOVA) followed by Tukey highly significant difference. Results: Both groups resulted in decrease in probing depth (group A, 3.0 mm; group B, 2.83 mm) and gain in clinical attachment level (group A, 3.33 mm; group B, 3.0 mm) over a period of 6 months, which was statistically insignificant. Conclusion: Within the limitations of the present study, it can be concluded that both mineralized cancellous bone allograft (Puros ® ) or autogenous bone result in significant clinical improvements.
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Assessment of knowledge, attitude, and practices on fixed dose combinations among postgraduate dental students
Narayana R Vinnakota, V Krishna, V Viswanath, Zaheer Ahmed, Kamal S Shaik, Naveen K Boppana
December 2016, 6(9):243-247
DOI:10.4103/2231-0762.197206  PMID:28217544
Aim: To assess the knowledge, attitude, and practices of fixed dose combination drugs among postgraduate dental students. Materials and Methods: A cross-sectional study was carried out among postgraduate dental students of dental colleges in coastal Andhra Pradesh. Three colleges were randomly selected and students of all the three years were included. Data was collected from the specialities of oral medicine and radiology, oral surgery, endodontics, pedodontics, periodontics, and public health dentistry. The total sample was 90 postgraduate students; informed consent was obtained from the participants, and a pretested questionnaire was distributed to them. Data was analyzed using the Statistical Package for the Social Sciences version 20 software. Results: Out of 90 postgraduates, 33 were males and 57 were females. Thirty-five percent were aware of the essential medical list (EML), among them 11% were from oral medicine and radiology and 6.7% were from pedodontics. However, most of them were unaware of the number of fixed dose combination drugs present in the World Health Organization EML. None of them were able to name at least a single banned fixed dose combination drug. Most of them were unaware of the advantages and disadvantages of using fixed dose combination drugs. Amoxicillin with clavulanic acid was the most common drug prescribed by students (73.3%) followed by ofloxacin with ornidazole (54.4%), ibuprofen with paracetamol (53.3%), and sulfamethoxazole with trimethoprim (6%). Most of them were unaware of the rationality in using fixed dose combination drugs. Common sources of information were medical representatives 43 (47.8%), internet 39 (43.3%), and 12 (13.3%) reported using WHO EML. Conclusion: There is an urgent need to improve knowledge on the rationality for using fixed dose combination, EML, and banned fixed dose combination in India to the promote rational use of fixed dose combination.
  2,704 182 1
Analysis of plasma lipid peroxidation and antioxidant enzymes status in patients of oral leukoplakia: A case control study
Kumar Chandan Srivastava, Deepti Shrivastava
December 2016, 6(9):213-218
DOI:10.4103/2231-0762.197195  PMID:28217539
Aims and Objectives: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including oral cancer. Mostly, all oral cancer lesions are preceded by a stage of premalignancy. The present study aims to evaluate lipid peroxidation and antioxidant status in the venous blood of patients with different clinicopathologic stages of leukoplakia. Materials and Methods: A case control study was designed with the inclusion of 20 new cases of histopathologically proven leukoplakia of various clinical stages along with an equal number of positive and negative control individuals. The concentrations of thiobarbituric acid reactive substances and the activities of the antioxidant enzymes, namely superoxide dismutase, reduced glutathione, glutathione peroxidase, and catalase, were estimated in plasma using spectrophotometric methods. The data are expressed as mean ± SD. The statistical comparisons between and within the study groups were performed by one-way analysis of variance followed by post hoc analysis. Karl Pearson correlation was performed for the biochemical parameters within the group and between the groups. For statistically significant correlations, simple linear regression was performed. Results: Significant enhanced lipid peroxidation (P < 0.001) with a decrease in antioxidants (P < 0.001) was observed in the venous blood of leukoplakia patients compared with positive as well as negative controls. Accordingly, significant (P < 0.001) pattern of progression in thiobarbituric acid reactive substances levels was observed at various clinical stages among patients of both control groups. Among enzymes, glutathione showed significant (P < 0.001) reduction along the stages on comparison with two control groups. Conclusion: Enhanced lipid peroxidation and compromised antioxidant defense in plasma indicate the development of oxidative stress. Among the antioxidant enzymes, reduced glutathione and glutathione Pperoxidase may play a decisive role in malignant transformation.
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